Three representative Nedd4L variants (296921-296923delTTG, rs2288774, and rs2288775) were found to be related to EH in the general Kazakh population in a case survey study among Kazakh women, suggesting that the Nedd4L gene variant may be associated with the essential hypertension in Kazakh’s women [61]. Here, NEDD4L is linked to hypertensive disorder.