Meta-analysis of the transcriptional landscapes of microglia in diverse neuropathological diseases including AD, tauopathy, EAE, LPS endotoxemia, as well as GFAP-IL6 and GFAP-IFN mice, identified a core microglial cell transcriptional response, termed danger response genes, which were similarly regulated in most of the disease states studied. This evidence concerns the gene IL6 and Alzheimer disease.