DNMT1 and colorectal carcinoma: In addition, DNMT1 and DNMT3B can be targeted by some miRNAs, such as miR-342, miR-124, and miR-506, thereby reducing the global DNA methylation level to restore the expression of tumor suppressive genes, such as E-cadherin, MGMT, P16, ADAM23, Hint1, RASSF1A, and RECK, thus further inhibiting the metastatic potential of CRC[120, 121].