Ma et al[131] found that the downregulation of TET1 inhibited the migration of CRC cells; they further found that TET1 regulates hypoxia-responsive genes such as VEGF, Glut1, and EPO by mediating the binding of HIF-1α to hypoxia-response element (HREs) of these genes by changing their CpG methylation levels (Table 2). This evidence concerns the gene HIF1A and colorectal carcinoma.