PCAF controls gene transcription by promoting the acetylation of H3K9[27], H3K14[28], and H4[29]; moreover, PCAF accelerates the acetylation of some nonhistone proteins, such as EZH2[30], PGK1[31], p53[32], and PTEN[33], to take part in the process of tumor progression. Here, PTEN is linked to neoplasm.