SIRT7-mediated K3 and K243 deacetylation of WDR77 reduces WDR77 interaction with PRMT5 and further affects the transmethylase activity of the WDR77/PRMT5 complex, resulting in a reduction in H4R3me2 modification, which is related to the migration ability of CRC cells[96]. The gene discussed is SIRT7; the disease is colorectal carcinoma.