SIRT6 and neoplasm: Controversially, many researchers have pointed out that SIRT6 and SIRT7 play a tumor inhibitory role via a variety of mechanisms, such as antagonizing the c-myc oncogene, regulating the DNA damage response, and inhibiting JAK2/STAT3 and PTEN/AKT signaling[54–57], but their roles in CRC metastasis were not discussed in these articles.