SIRT1 and colorectal carcinoma: Because of the crucial role of CSCs in CRC metastasis, Wang et al. found that SIRT1 could decrease H3K9ac enrichment on the promoter of miR-1185-1 and thus cause chromatin remodeling to repress miR-1185-1 expression, which further upregulated the CD24 level to promote the stemness and migration of CRC cells[52].