The increased serum CRP, an acute response protein release from liver known to be associated with CVD, and the decreased serum PON1, an antioxidant enzyme protecting HDL-C from oxidation, ApoA1, a HDL-C associated protein known to play an role in maintaining HDL-C function, and 6-keto-PGF1α, a non-enzymatic hydrolysis product of prostacyclin that functions as vessel dilator, by high-dose CM in the obese rats suggest a further increase in the risk for CVD and hypertension in these rats. This evidence concerns the gene APOA1 and Hypertension.