Deregulation of BA homeostasis marked by the expression of hepatic BA transporters (BSEP, OSTα/β, MRP2, MDR2-3, NTCP) is diminished leading to increased hepatic BA sequestration and inflammation and reduced FXR signaling [200–203] in liver cirrhosis and nonalcoholic steatohepatitis that are risk factors for the development of HCC. The gene discussed is NR1H4; the disease is hepatocellular carcinoma.