Preclinical studies have signified that glycolytic inhibitors, such as chrysin (targeting HK2),41 2‐DG (targeting HK2),42, 43 proanthocyanidin B2 (targeting PKM2),28 methyl jasmonate (targeting HK2)44 and genistein (targeting HIF‐1α),45 suppress proliferation and induce apoptosis of the HCC cells. The gene discussed is HK2; the disease is hepatocellular carcinoma.