NLRP3 and neurodegenerative disease: Although other air pollutants have been shown to activate NLRP3 inflammasome and mediate pulmonary, cardiovascular, and neurodegenerative diseases (Saresella et al.2016; Zheng et al.2018; Du et al.2019), the effect of CS on the activation/inhibition of NLRP3 is still controversial and under debate.