Whereas pancreatic NETs exhibit frequently genetic alterations in MEN1, DAXX, ATRX, MUTYH, CHEK2, BRCA2, and genes involved in the mammalian target of rapamycin (mTOR) signaling pathway (Jiao et al. 2011; Scarpa et al. 2017), NECs more commonly demonstrate mutations in TP53 and RB1 (Yachida et al. 2012; Takizawa et al. 2015). Here, MTOR is linked to pancreatic neuroendocrine tumor.