BIRC5 and cancer: Although results from first clinical Phase I and II trials demonstrated rather frustrating results even in combination with chemotherapeutics, achieving maximally partial response rates, survivin seems to remain an attractive target for cancer treatment (Tolcher et al. 2008, 2012; Giaccone et al. 2009; Satoh et al. 2009; Lewis et al. 2011; Kelly et al. 2013; Clemens et al. 2015; Kudchadkar et al. 2015; Papadopoulos et al. 2016; Shimizu et al. 2020).