Since the categories of highly differentiated neuroendocrine tumor and carcinoma (WHO classification 2000) (Solcia et al. 2000) corresponds to the G1/G2 NET of the WHO classification 2010 (Rindi et al. 2010), and the poorly differentiated NEN are defined as NEC (Anlauf 2011), we compared survivin expression between G1/G2 tumors (highly differentiated neuroendocrine tumor and carcinoma) and G3 NEC (poorly differentiated NEN). This evidence concerns the gene BIRC5 and neuroendocrine carcinoma.