Our data suggest that, in melanoma cells, the process of sCD160 production is constitutive and occurs through a classical protein secretion pathway as it remained exclusively detected at the cytoplasmic level but not at the cell surface, even after cell treatments known to induce expression of membrane-associated proteins such as PD-L1 (e.g. INF-\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\gamma$$\end{document}γ [22]). Here, CD274 is linked to melanoma.