CD274 and neoplasm: Exhibiting prognostic and predictive features of a high tumor mutational burden, a high neoantigen load, and an immune-active tumor microenvironment (TME) characterized by high levels of tumor-infiltrating lymphocytes and overexpression of immune checkpoint molecules, cancers with MSI are known to be great candidates for immune checkpoint inhibitors (ICIs) treatment, such as pembrolizumab and atezolizumab (anti-PD-1 and anti-PD-L1 monoclonal antibody, respectively)4,5.