MSH6 and colorectal carcinoma: Although MAP reflects the characteristics of sporadic MSI CRC well, MSH2/MSH6-negative MSI CRC reflection is somewhat limited because the expression patterns of MSH2 and MSH6 among MMR genes are not distinctly distinguished from MSS and MSI in TCGA and external validation dataset and information on each MMR gene-negative phenotype was not available in the TCGA clinical information, so it was not considered during training.