In addition, the expression pattern of the signature of preMSIm did not appear to suitably reflect genes important in gastric cancer, such as DDX27, SMAP1, and ZSWIM3, and in uterine cancer, such as DDX27, SHROMM4, SMAP1, and ZSWIM3, thereby making it unable to efficiently differentiate MSI and MSS tumors (|log2 fold change|< 0.5) in these cancer types (Fig. 3d,e). Here, DDX27 is linked to gastric cancer.