Additionally, the haplotype analyses were performed showing that the NLRP3 block 1 C-G-A-C, C-G-A-G, C-G-G-G, or T-G-G-G haplotypes significantly decreased the OR of CKD compared to that of the C-A-A-C haplotype (which includes the NLRP3 rs4925650 A allele). The gene discussed is NLRP3; the disease is chronic kidney disease.