Hence, the effect of NLRP3 rs4925650 GA/AA genotypes and NLRP3 rs10157379 CT/TT genotypes on susceptibility to CKD appears to be independent of age, sex, educational level, consumption of tea, alcohol, and coffee, analgesic usage, and disease histories of diabetes and hypertension. This evidence concerns the gene NLRP3 and hypertensive disorder.