NR1D1 and type 2 diabetes mellitus: Finally, a meta-analysis of publicly available 5 human islet microarray datasets (GSE25724, 76894, 38642, 76895, and 20966) comparing the transcriptome of ND and T2DM islets revealed significant downregulation of genes annotated as REV-ERBα footprints (unique to T2DM conditions) in human T2DM islets (Fig. 9F, P = 0.01).