Given the key role of the ubiquitination process in autophagy [27] and the existence of interplay between autophagy and the ubiquitin-proteasome system in β-cells [41], it is not surprising that these data further reveal a wider role of REV-ERBα in the modulation of protein degradation in T2DM islets. The gene discussed is NR1D1; the disease is type 2 diabetes mellitus.