Chi-square analysis revealed that high expression of RTN2 was positively correlated with older age (P = 0.009), more vessel invasion (P = 0.018), tumour invasion depth (P = 0.030), lymph node metastasis (P = 0.026) and advanced TNM (tumour node metastasis) stage (P = 0.012) (Table 1). The gene discussed is RTN2; the disease is metastatic malignant neoplasm in the lymph nodes.