Further assess based on multivariate Cox regression analyses illustrated that tumour vessel invasion (HR, 1.583; 95% CI, 1.070–2.343; P = 0.022), TNM stage (HR, 3.090; 95% CI, 1.893–5.042; P < 0.001), and RTN2 expression (HR, 3.031; 95% CI, 1.978–4.645; P < 0.001) had independent prognostic significance for overall survival of gastric cancer patients (Fig. 2A). Here, RTN2 is linked to neoplasm.