CD274 and cancer: In recent years, lots of immunotherapy drugs, from monoclonal antibody against cytotoxic-T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1) and PD-1 ligand 1 (PD-L1), to CAR T cell therapy, are approved by U.S. Food and Drug Administration (FDA) for cancer treatment [54–57].