In this phase III trial, the efficacy and safety of nivolumab is being compared with that of bevacizumab (a monoclonal antibody to vascular endothelial growth factor) in patients with recurrent glioblastoma, the preliminary data reported at the 2017 World Federation of Neuro-Oncology Societies meeting revealed that at interim analysis of 369 patients, nivolumab monotherapy did not demonstrate a median OS benefit over bevacizumab (9.8 months with nivolumab versus 10.0 months bevacizumab) [45]. The gene discussed is VEGFA; the disease is glioblastoma.