In a study by Guo et al., hypercytokinemia, especially pro-inflammatory cytokines like IL-1β, IL-6, IP-10, G-CSF, IL-8, IL-17, TNF-alpha, and IFN-gamma were seen in patients with COVID-19 and were positively associated with disease severity, multi-organ failure, and death [15, 25, 26]. The gene discussed is CSF3; the disease is COVID-19.