Compared with patients with non-severe sarcopenia, severely sarcopenic patients were older, showed different marital status, and had a higher percentage of ADL or IADL impairment as well as multiple comorbidities (≥2); they also showed significantly higher levels of HDL and RDW-CV but lower levels of ALT and FT3 (P < 0.05). The gene discussed is GPT; the disease is sarcopenia.