MSH6 and cancer: Many studies have explored the association between germline variants and somatic aberrations [26, 27], and carriers of germline variants in our study are already known as high penetrance mutants for cancer development, e.g., P/LP germline mutations in 12 genes (BARD1, BRCA1, BRCA2, BRIP1, PALB2, RAD51C, RAD51D, MSH2, MLH1, PMS2, MSH6, and EPCAM) are known or suspected to increase the risk of ovarian cancer [28].