The adjusted HRs for serious non-AIDS events, comparing CD4/CD8 ratio ≤ 0.4 versus CD4/CD8 ratio > 0.4, varied from 1.39 (95%CI 0.96, 2.02) in non-late to 1.62 (95%CI 1.10, 2.40) in late, and 1.49 (95%CI 0.97, 2.29) in advanced presenters. The gene discussed is CD4; the disease is AIDS.