CRP and atherosclerosis: However, although we found a significant association in the total women group and in the non-estrogen user group between H4/ACCCA and cIMT (Total women Median carriers vs non-carriers: 0.51–0.49; p = 0.002; NEU Median carriers vs non-carriers: 0.51–0.49; p = 0.010; Additional file 1: Table S2), the trend was opposite compared to CRP levels (Additional file 1: Table S2; Table 5), why it is difficult to draw any clear conclusions on the role of these genotypes or haplotypes and its effects on preclinical signs of atherosclerosis.