CCN4 and pachyonychia congenita: The top upregulated genes included COL11A1, (Jia et al. 2016) MMP11 (Zhang et al. 2020), MARCO (Shi et al. 2021), GJB2 (Zhou et al. 2019), CD163 (Shi et al. 2021), and CCN4 (Banerjee et al. 2016) (Additional file 3: Table S3) in the high expression of FN1 group, which were highly correlated with a poor prognosis of patients with PC.