This analysis confirmed that the risk factor dyslipidemia (P = 0.989) did not contribute to the statistically significant differences observed between groups, discarding possible confounders among the demographic conditions and the studied proteins and elements, and therefore the altered levels of MT1A, S100A6, LF, Fe, and Cu in the tear film between both cohorts are result of AMD disease. Here, S100A6 is linked to metabolic syndrome.