ANXA1 and wet macular degeneration: Recently, the tear film of 15 patients with wet AMD and 15 age-matched healthy controls was comparatively analyzed by two-dimensional gel electrophoresis and MALDI-TOF/TOF, which identified altered proteins belong to pathways involving oxidative stress, protein clearance and chronic inflammation pathways, highlighting annexins A1 and A4 are part of the calcium-dependent phospholipid-binding family that regulate inflammation and autophagy.52