From the identification of 342 proteins, shootin-1, histatin-3, fidgetin-like protein 1, SRC kinase signaling inhibitor, Grave's disease carrier protein, actin cytoplasmic 1, prolactin-inducible protein 1 and protein S100-A7A were found up-regulated in the tear film of dry AMD patients, involving specific pathways related to oxidative stress, inflammation, and proteolysis. Here, SHTN1 is linked to dry age related macular degeneration.