The result showed that the expression level of miR-339-5p was abnormally lower in APP/PS1 mice compared with WT littermates (Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/JCI149160DS1) and was comparable to the downregulation of miR-16, a verified posttranslational regulator of APP in an AD model (21, 22). This evidence concerns the gene APP and Alzheimer disease.