For example, Feng et al screened 1459 differentially expressed lncRNAs and 2381 DEGs in advanced laryngeal squamous cell carcinoma by lncRNA and mRNA integrated microarrays11; Recently, HOTTIP was found to be a key candidate biomarker by Yin et al and SERPINE1, PLAU, and ACTA1 could act as biomarkers in HNSCC detected by Yang et al via integrated bioinformatics analysis.10, 12. Here, PLAU is linked to head and neck squamous cell carcinoma.