Based on microarray analyses, we found that known oncogenes in GC, including ErbB2, Cdkn2a, MAX, TERT, K-Ras, N-Ras, Cyclin E, c-Met and FGFR2, were upregulated at 14 months of age, whereas the tumor suppressors P53, CDH1 and APC were downregulated (Fig. 2, a). This evidence concerns the gene APC and gastric cancer.