OPA3 and dilated cardiomyopathy: Other mitochondrial proteins that increased during surgery in the RV include proteins involved in protein biosynthesis (mitochondrial Isoleucine--tRNA ligase), mitochondrial dicarboxylate carrier (solute carrier family 25 member 10) and the optic atrophy 3 protein (OPA3) which is in the inner mitochondrial membrane (36) and implicated in dilated cardiomyopathy (37).