Other proteins that increase in LV of CAD patients during surgery which are likely to originate outside the myocardium include neutrophil elastase [likely due to activation of neutrophils triggered by cardiopulmonary bypass (26)], coronin-1A [predominantly expressed in leukocytes and important for integrin-mediated leukocyte adhesion (27)] and myeloperoxidase [likely due to its release by neutrophils, and linked to adverse left ventricular remodeling following myocardial ischemia (28)]. This evidence concerns the gene MPO and myocardial ischemia.