TNF-α was considered to have proinflammatory effects via binding to its TNFR-1 and TNFR-2 receptors [14], and the expressions of TNFR1 and TNFR-2 were associated with higher risk of myocardial infarctions [15]. The gene discussed is TNFRSF1B; the disease is myocardial infarction.