By multivariate regression analysis, TLR2, TLR3, TLR4, TNF-α, sTNFR-1, sTNFR-2, EPCs, and VEGF were found to be independent indicators of RMI after adjustment for age, gender, family history of myocardial infarction (MI), alcohol consumption, smoking, and diseases (stable angina pectoris, unstable angina pectoris, hypertension, and diabetes mellitus) in all patients. Here, TLR4 is linked to myocardial infarction.