Cut-off values and ORs (95% CI) for the risk of developing severe/critical COVID-19 in the univariate and multivariate analyses for News-2, Ferritin, CRP and NLR (model 1), for the cytokines sCD25, IL1Ra and IL18 (model 2) and for activated CD4 and CD8, NK, Tc2 and EMRA CD8 (model 3). This evidence concerns the gene IL18 and COVID-19.