According to the study jointly conducted by GSI Helmholtzzentrum für Schwerionenforschung GmbH (Germany) and National Institute of Radiological Sciences (Japan), particle beam combined with dual immune checkpoint inhibitors (anti-CTLA-4 and anti-PD-1) induced a higher antimetastasis effect compared with photon beam at the equivalent dose of same primary tumor control level (42). This evidence concerns the gene CTLA4 and neoplasm.