The underlying mechanism has been speculated to be the migratory effect of uPA–uPAR–PAI-1 systems on endothelial cells, with fibrin deposition playing an important role in tumor angiogenesis (60); SERPINE1 also functions as an extracellular matrix (ECM) component to stabilize tumor cell adhesion in migration (61). This evidence concerns the gene SERPINE1 and neoplasm.