TTR and metastatic malignant neoplasm in the lymph nodes: Univariate Cox regression analysis revealed that decreased serum prealbumin [<210 mg/L, hazard ratio (HR) = 4.107, p = 0.067], decreased peripheral lymphocyte count (<1.65 * 109/L, HR = 8.045, p = 0.046), FR+ CTC level (≥12.6 FU/3 ml, HR = 6.898, p = 0.003), CEA level (>5 ng/ml, HR = 4.82, p = 0.006), CA19-9 level (>34 ng/ml, HR = 3.084, p = 0.07), and lymph node metastasis (HR = 5.002, p = 0.015) were significantly associated with shorter RFS (Figure 4).