TIGIT and familial pancreatic carcinoma: Although no significant correlation was found between expression levels of KPNA4 and those of PDCD1 (PD-1), CTLA4, LAG3 or TIGIT (Figures 5F, G and Supplementary Figures 2A, B), we did find KPNA4 was closely associated with HAVCR2 (Figure 5H), which encodes the immune checkpoint receptor TIM3 and is tightly associated with poor prognosis of pancreatic cancer (40).