Based on SCCLG-ALL-2016 multicenter study, a nomogram incorporating age at diagnosis, WBC at diagnosis, phenotype, ETV6-RUNX1/TEL-AML1 fusion status, D15-BMR, and D15-MRD was constructed by LASSO and multivariate Cox analysis to predict EFS probability in children with ALL. Here, RUNX1 is linked to acute lymphoblastic leukemia.