EGFR and adenocarcinoma: Lung puncture biopsy was diagnosed as adenocarcinoma, and immunohistochemistry showed a negative PD-L1 expression with TMB: 6.38 mut/bp; NGS revealed that the patient had EGFR exon 21 L858R point mutation, combined with HEBB2 amplification, EGFR amplification, and TP53 mutation; and the clinical stage was IIIA (T2N2M0).