Kasperkiewicz et al. investigated the link between vaccines against SARS-CoV-2 and the evolution of autoimmunity by testing serum samples for autoantibodies to the main immunobullous autoantigens (desmoglein 1, desmoglein 3, envoplakin, BP180, BP230, and type VII collagen) on 12 seropositive post-COVID-19 individuals and 12 seropositive healthy volunteers who received two doses of the Pfizer-BioNTech mRNA COVID-19 vaccine. Here, DSG3 is linked to Autoimmunity.