Findings yielded by first-trimester screening tests further demonstrate that low PAPP-A levels are linked with an increased risk of pregnancy complications such as spontaneous fetal loss, low birth weight, IUGR, pregnancy-induced hypertension, preeclampsia, preterm birth, preterm rupture of membranes, and placental bleeding and abruption [8-10]. The gene discussed is PAPPA; the disease is preeclampsia.