BRAF and cancer: Several human cancers include the BRAF (V600E) mutation, which causes an increase in cell proliferation by altering the ERK/MAPK signaling cascade.24 While c-Met inhibitors have demonstrated potential anti-tumor effectiveness in pre-clinical and early phase clinical studies in a variety of tumor types, but the majority of phase III trials with these agents have had poor findings.25 So, an ideal method for combating cancer is the development of small molecules that exhibit multitarget and multifunctional behaviour and this research is an attempt to discover such multifunctional molecules.