In the human genome, about 376 000 putative motifs are present, which tend to form a G-quadruplex structure.1,2 Depending upon their location, G-quadruplex motifs act as gene regulators via regulating various essential biological processes like telomeric maintenance and control the transcription and translation of various protooncogene oncogene's promoter (c-Myc, c-kit, k-ras, and bcl-2) regions.3–10 c-Myc is an important regulator for the processes of normal cellular growth regulation and differentiation, and its dysregulation is one of the hallmarks of many cancers. Here, MYC is linked to cancer.