The RSK family has various cytoplasmic and nuclear targets that can be alluded to as transcription factors (TIF1A, CREB, serum response factor, NF-κB), several ribosome-associated proteins related to the protein synthesis (eIF4B and ribosomal protein S6), and cell-survival signals (Bcl2).13 The dysregulated expression of RSK causes several human diseases comprising brain injury, cancer, cardiac hypertrophy, diabetes, and inflammation. The gene discussed is RPS6KA1; the disease is diabetes mellitus.