Dual-targeting hybrid nanoparticles made of PLGA and a lipoid shell prepared by conjugating the anti-HER2/neu peptides (AHNP) and n-hexadecylamine (HDA) to the carboxyl groups of hyaluronic acid (HA) were reported to deliver 7-ethyl-10-hydroxycamptothecin (SN38 agent) specifically to gastric cancer cells (HGC27 cells) with overexpression of (1) CD44 cluster determinant 44 and (2) HER2 (human epidermal growth factor receptor 2). The gene discussed is CD44; the disease is gastric cancer.