Only DPX 30 and 60 mg has been registered by European Union agency (EMA) as a rapid-acting SSRI for the treatment of PME on-demand, while other treatments are considered off-label.6 Moreover, some studies suggest that the SSRI paroxetine (PRX) may be administered to treat premature ejaculation.7 Citalopram (CTP) is another SSRI recommended by some studies for the treatment of premature ejaculation.8 Due to the popularity, PDE-5 inhibitors (SLD, VAR and TAD) and products containing these compounds are often subjected to counterfeiting. The gene discussed is PDE5A; the disease is premature ejaculation.