Therefore, feedback-resistant mutations are successfully made in genes encoding for LysC (aspartate kinase).2,9,11 Apart from the enzymological interest, AK is an attractive target for developing new antibiotics and antitubercular drugs because of its absence in human and animals.12 For example, PaAK plays crucial roles in biofilm-associated antibiotic-resistance and infections, which demonstrates its potential application in anti-P. aeruginosa treatment.13,14Mycobacterium tuberculosis (Mtb) AK has been identified as a potential drug target in Mtb, especially in multidrug-resistant Mtb. This evidence concerns the gene ADK and infection.