Biomarkers are molecular, biochemical, or cellular variations measurable in biological samples that indicate any biological, pathogenic, or therapeutic response.7 Recent bibliography reported the development of several aptasensors and immunosensors for malaria based on biomarkers detection, like histidine-rich protein II (HRP-2),8–10 lactate dehydrogenase (LDH),11–13 aldolase (ALD),14 hypoxanthine-guanine phosphoribosyl transferase (HGPRT),15 glutamate dehydrogenase (GluDH),16 and products such as hemozoin.17 The gene discussed is HPRT1; the disease is malaria.