In contrast to our findings in B16 melanoma cells, CM from ApcMin/+Dro1/Ccdc80knockout PSC did not affect activity of caspase-3/7 in apoptosis induced intestinal epithelial cells, suggesting no modulatory role for DRO1/CCDC80 in apoptosis in the intestinal epithelium. This evidence concerns the gene CASP3 and melanoma.