Similarly, despite Dro1/Ccdc80’s strong tumor suppressive function in ApcMin/+ mice as well as chemically-induced colon carcinogenesis [1, 6], ubiquitous loss of DRO1/CCDC80 alone was insufficient to induce spontaneous colonic tumor development in C57BL/6 mice [1]. This evidence concerns the gene CCDC80 and colonic neoplasm.