P-Akt levels were decreased in the CCH 8-week group but activated in the NBP-treated group, coinciding with the results that NBP activated PI3K/Akt in oxygen-glucose deprivation/reperfusion (OGD/R) [93], the animal model of depression [94], MCAO rats [31], and bone marrow stem cells (BMSCs) [95]. Here, AKT1 is linked to depressive symptom measurement.