WDHD1 and cancer: But for tumor cells, WDHD1 is necessary for DNA replication and effective progression and homologous recombination repair in S phase, and the deletion of WDHD1 increases the accumulation of DNA damage, delays the progression of S phase, halts the cell cycle in late S phase to G2 phase, leads to the accumulation of cells in late S phase and/or G2 phase, and induces the death of cancer cells [35].