The pathogenesis of esophageal cancer has not been thoroughly studied, but abnormal gene expression is still considered to be an important factor for the occurrence of esophageal cancer, and some studies have pointed out that WD repeat and HMG-box DNA binding protein 1 (WDHD1) is the hub gene in the occurrence of esophageal cancer [17]. The gene discussed is WDHD1; the disease is esophageal cancer.