The discovery of a link between RELN pathogenic variants and an autosomal recessive form of lissencephaly with cerebellar hypoplasia (Lissencephaly type 2, LIS2, OMIM #257320) questioned the use of the reeler mouse as a model to study neuropsychiatric conditions in humans, including autism (Hong et al., 2000). Here, RELN is linked to lissencephaly spectrum disorders.