Zhu et al. (2021) found that miR-520b targeting PTEN promoted the polarization of M0 macrophages toward M2 in breast cancer. BCL6 promotes the differentiation of B cells into plasma cells by inducing the production of Blimp-1 (Alinikula et al., 2011; Yasuda et al., 2011). BCL6 promotes apoptosis of neutrophils at tissue infection sites and regulates the development of disease (Zhu et al., 2019). This evidence concerns the gene PTEN and breast carcinoma.