Zhu et al. (2021) found that miR-520b targeting PTEN promoted the polarization of M0 macrophages toward M2 in breast cancer. BCL6 promotes the differentiation of B cells into plasma cells by inducing the production of Blimp-1 (Alinikula et al., 2011; Yasuda et al., 2011). BCL6 promotes apoptosis of neutrophils at tissue infection sites and regulates the development of disease (Zhu et al., 2019). The gene discussed is PRDM1; the disease is breast cancer.