Huang et al. (2019) found that circNfix induces heart regeneration after MI by targeting the miR-124/Gsk3β axis. Si et al. (2020) revealed the role of circHipk3 in MI, and they found that circHipk3 promotes angiogenesis after MI via regulating CTGF by sponging miR-133. Meanwhile, circ-Ttc3 has also been reported to participate in the protection of cardiac function after MI by interacting with miR-15b and regulating the expression of ARL2 (Cai et al., 2019). The gene discussed is ARL2; the disease is myocardial infarction.