Proteins such as neuronal (N)-cadherin, epithelial (E)-cadherin, vascular-endothelial (VE)-cadherin, EGFR ligands, β-cellulin (BTC), EGF and the low affinity IgE receptor CD23 are secreted into the TME that enhances tumor survival, migration and apoptosis. The gene discussed is CDH17; the disease is neoplasm.