By comparing the clinical phenotypes between the two groups, we found that there were no statistical differences in gender, ALT, AFP, and tumor size in the GSE14520 dataset, which contains more clinical phenotype data, while multinodular, cirrhosis, Barcelona Clinic Liver Cancer (BCLC) and Cancer of the Liver Italian Program were statistically different (P-value <0.05). The gene discussed is AFP; the disease is cancer.