CRP and COVID-19: In contrast, negative correlations between IL-22R1+ classical and intermediate monocytes and CRP levels, and IL-22R1+ intermediate monocytes and plasma IL-6 and IFN-α in non-severe patients suggest a beneficial role of IL-22R1 expressing cells in COVID-19 as CRP, IL-6, and IFN-α are predictors of lung injury and indicate the severity of SARS-CoV-2 infection (47, 48).